|Western Blot (WB)||1:500|
|Western Blot (WB)||See 2 publications below|
|Tested Species reactivity||Mouse|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues T(35) C I L R E E A R M P Q S T G(49) of mouse LXR alpha.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-332 detects LXR alpha in mouse samples.
PA1-332 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing LXR alpha in mouse liver samples.
The PA1-332 immunogen is a synthetic peptide corresponding to residues T(35) C I L R E E A R M P Q S T G(49) of mouse LXR alpha. The PA1-332 immunizing peptide (Cat. # PEP-272) is available for use in neutralization and control experiments.
Liver X receptors (LXRs), also known as RLD1, are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once activated by their respective oxysterol ligands. Two known isoforms, alpha and beta, are differentially expressed; the alpha isoform predominantly expressed in liver, whereas beta isoform expression has been shown to be ubiquitous.
The corresponding gene for the LXR alpha is NR1H3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Liver X Receptor Alpha; LXR alpha; Nuclear orphan receptor LXR-alpha; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1
Gene Aliases: AU018371; LXR; Lxra; Nr1h3; RLD1; Unr1
UniProt ID: (Mouse) Q9Z0Y9
Entrez Gene ID: (Mouse) 22259
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