Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
PA1-332 detects LXR alpha in mouse samples.
PA1-332 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing LXR alpha in mouse liver samples.
The PA1-332 immunogen is a synthetic peptide corresponding to residues T(35) C I L R E E A R M P Q S T G(49) of mouse LXR alpha. The PA1-332 immunizing peptide (Cat. # PEP-272) is available for use in neutralization and control experiments.
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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