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|Tested species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues T(35) C I L R E E A R M P Q S T G(49) of mouse LXR alpha.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-332 detects LXR alpha in mouse samples.
PA1-332 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing LXR alpha in mouse liver samples.
The PA1-332 immunogen is a synthetic peptide corresponding to residues T(35) C I L R E E A R M P Q S T G(49) of mouse LXR alpha. The PA1-332 immunizing peptide (Cat. # PEP-272) is available for use in neutralization and control experiments.
Liver X receptors (LXRs), also known as RLD1, are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once activated by their respective oxysterol ligands. Two known isoforms, alpha and beta, are differentially expressed; the alpha isoform predominantly expressed in liver, whereas beta isoform expression has been shown to be ubiquitous.
The corresponding gene for the LXR alpha is NR1H3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Liver X Receptor Alpha; LXR alpha; Nuclear orphan receptor LXR-alpha; oxysterols receptor LXR-alpha; ubiquitously-expressed nuclear receptor 1
AU018371; LXR; Lxra; Nr1h3; RLD1; Unr1