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Invitrogen

LXR alpha/beta Polyclonal Antibody

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LXR alpha/beta Polyclonal Antibody

Product Details

PA1-331B

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2154886

Product Specific Information

PA1-331B detects recombinant human liver X receptor (LXR).



PA1-331B has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~64 kDa and ~80 kDa protein representing recombinant human LXR alpha and beta.



The PA1-331B immunogen is a synthetic peptide corresponding to residues C L(432) R L Q D K K L P P L L S E(445) of human LXR alpha. This sequence also corresponds to amino acids 442-455 of the human LXR beta. PA1-331B immunizing peptide (Cat. # PEP-115) is available for use in neutralization and control experiments.

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activiation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiqutination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X Receptor; Liver X receptor alpha; Liver X receptor beta; LX receptor beta; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR-alpha; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; unnamed protein product

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Gene Aliases: LXR-a; LXR-b; LXRA; LXRB; NER; NER-I; NR1H2; NR1H3; RIP15; RLD-1; UNR

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UniProt ID: (Human) P55055, (Human) Q13133

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Entrez Gene ID: (Human) 7376, (Human) 10062

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding apolipoprotein A-I receptor binding sequence-specific DNA binding metal ion binding retinoid X receptor binding ATPase binding transcription regulatory region sequence-specific DNA binding cholesterol binding sterol response element binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process hormone-mediated signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux regulation of lipid storage positive regulation of lipid storage negative regulation of cholesterol storage cell differentiation intracellular receptor signaling pathway response to nutrient levels negative regulation of lipid transport positive regulation of cholesterol transport phosphatidylcholine acyl-chain remodeling cholesterol homeostasis mRNA transcription from RNA polymerase II promoter positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway negative regulation of pinocytosis negative regulation of inflammatory response lipid homeostasis negative regulation of interferon-gamma-mediated signaling pathway positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes negative regulation of cold-induced thermogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of response to endoplasmic reticulum stress response to progesterone positive regulation of toll-like receptor 4 signaling pathway regulation of circadian rhythm negative regulation of macrophage activation apoptotic cell clearance positive regulation of lipid biosynthetic process sterol homeostasis triglyceride homeostasis cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes
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