PA1-333 detects LXR beta in human, rat and mouse samples.
PA1-333 has been successfully used in Western blot and IF procedures. By Western blot, this antibody detects an ~51 kDa protein representing LXR beta in rat and mouse liver samples.
The PA1-333 immunogen is a synthetic peptide corresponding to residues R(113) Y A C R G S G T C Q M D A(126) of rat LXR beta. The PA1-333 immunizing peptide (Cat. # PEP-271) is available for use in neutralization and control experiments.
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR beta; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Orphan nuclear receptor OR-1; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; steroid hormone-nuclear receptor NER; ubiquitous receptor; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; UR
Gene Aliases: AI194859; LXR; LXR-b; LXRB; LXRbeta; NER; NER-I; NER1; NR1H2; OR-1; RIP15; UNR; Unr2; UR