PA5-29771 targets LXR beta in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29771 immunogen is recombinant protein fragment corresponding to a region within amino acids 162 and 325 of Human LXR beta.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).
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Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; liver X receptor-beta; LX receptor beta; LXR beta; LXR-b; LXRB; NER; NER-I; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; Retinoid X receptor-interacting protein No.15; RIP15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2
Gene Aliases: AI194859; LXR; LXR-b; LXRB; LXRbeta; NER; NER-I; NER1; NR1H2; OR-1; RIP15; UNR; Unr2; UR