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Invitrogen
LZIP Polyclonal Antibody
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Product Details
PA5-121011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein (or fragment)
Conjugate
Form
Liquid
Concentration
2.24 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Jurkat, HeLa, 293T, HepG2, Mouse brain, Mouse liver, Mouse pancreas. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum membrane, Membrane, Nucleus, Single-pass type II membrane protein.
Immunogen sequence: MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE GTQMTPQHME ELAEQEIARL VLTDEEKSLL EKEGLILPET LPLTKTEEQI LKRVRRKIRN KRSAQESRRK KKVYVGGLES RVLKYTAQNM ELQNKVQLLE EQNLSLLDQL RKLQAMVIEI SNKTSSSSTC
Target Information
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic leucine zipper protein; cAMP-responsive element-binding protein 3; CREB-3; cyclic AMP response element (CRE)-binding protein/activating transcription factor 1; Cyclic AMP-responsive element-binding protein 3; leucin zipper proitein; Leucine zipper protein; Luman; small leucine zipper protein; transcription factor LZIP; Transcription factor LZIP-alpha
Gene Aliases: AU044960; AW538053; C80076; CREB3; LUMAN; LZIP; LZIP-1; LZIP-2; sLZIP
UniProt ID: (Human) O43889
Entrez Gene ID: (Human) 10488, (Mouse) 12913, (Rat) 298400
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
cAMP response element binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
cAMP response element binding protein binding
CCR1 chemokine receptor binding
protein homodimerization activity
sequence-specific DNA binding
regulation of cell growth
positive regulation of defense response to virus by host
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
chemotaxis
response to unfolded protein
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
establishment of viral latency
release from viral latency
positive regulation of cell migration
endoplasmic reticulum unfolded protein response
regulation of cell proliferation
cytoplasmic sequestering of transcription factor
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of calcium ion transport
positive regulation of monocyte chemotaxis
positive regulation of deacetylase activity
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
viral process
response to endoplasmic reticulum stress
induction of positive chemotaxis
negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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