A suggested positive control is human heart tissue lysate.
PA5-20902 can be used with blocking peptide PEP-1016.
LZTR1, a member of the BTB-kelch superfamily, was initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Golgi complex. Deletion of this gene may be associated with DiGeorge syndrome, a developmental field defect involving the third and fourth pharyngeal pouches, causing the absence of thymus and parathyroid glands, congenital cardiac abnormalities and facial dysmorphism. LZTR1 is tyrosine phosphorylated and subsequently degraded upon induction of apoptosis.
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Protein Aliases: leucine-zipper-like transcription regulator 1; Leucine-zipper-like transcriptional regulator 1; leucine-zipper-like transcriptional regulator, 1; LZTR-1; MGC21205
Gene Aliases: 1200003E21Rik; AI591627; AW550890; BTBD29; LZTR-1; LZTR1; NS10; SWNTS2; TCFL2
Molecular Function: basic leucine zipper transcription factor