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Rockland
LZTR2 Polyclonal Antibody
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FIGURE: 1 / 3
LZTR2 Antibody (600-401-CP3) in ICC/IF
Immunofluorescence Microscopy of LZTR2 antibody. Tissue: Mouse kidney tissue. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: LZTR2 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: LZTR2 is a membrane protein. Staining: LZTR2 as red fluorescent signal.
Product Details
600-401-CP3
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-LZTR2 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the C-terminus of human LZTR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine zipper transcription regulator 2; protein SEC16 homolog B; Protein transport protein Sec16B; Regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein; RGPR-p117; SEC16 homolog B
Gene Aliases: KIAA1928; LZTR2; PGPR-p117; RGPR; Rgpr-p117; SEC16B; SEC16S
UniProt ID: (Human) Q96JE7, (Mouse) Q91XT4, (Rat) Q75N33
Entrez Gene ID: (Human) 89866, (Mouse) 89867, (Rat) 89868
transport
endoplasmic reticulum organization
peroxisome organization
positive regulation of gene expression
protein transport
vesicle-mediated transport
peroxisome fission
COPII vesicle coating
positive regulation of protein exit from endoplasmic reticulum
protein localization to endoplasmic reticulum
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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