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Lactoferrin Polyclonal Antibody

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Lactoferrin Polyclonal Antibody

Product Details

BS-5810R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Lactoferrin, amino acids 611-710.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe; neutrophil lactoferrin; Talalactoferrin

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Gene Aliases: Csp82; GIG12; HEL110; HLF2; LF; LTF; MMS10R; Ms10r

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UniProt ID: (Human) P02788, (Mouse) P08071

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Entrez Gene ID: (Human) 4057, (Mouse) 17002, (Rat) 301034

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Function(s)
DNA binding serine-type endopeptidase activity iron ion binding protein binding heparin binding protein serine/threonine kinase activator activity peptidase activity serine-type peptidase activity hydrolase activity metal ion binding molecular_function ferric iron binding transfer/carrier protein
Process(es)
ossification regulation of cytokine production retina homeostasis innate immune response in mucosa transcription, DNA-templated proteolysis ion transport humoral immune response antibacterial humoral response antifungal humoral response negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity iron assimilation by chelation and transport positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling cellular protein metabolic process negative regulation by host of viral process negative regulation of viral genome replication cell redox homeostasis positive regulation of osteoblast differentiation negative regulation of viral process positive regulation of NF-kappaB transcription factor activity bone morphogenesis positive regulation of protein serine/threonine kinase activity positive regulation of bone mineralization involved in bone maturation negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development immune system process transport iron ion homeostasis iron ion transport cellular iron ion homeostasis biological_process
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