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Product Details
MUB2002P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
67D9
Immunogen
Lactoferrin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Monoclonal antibodies 67D2, 67D9 and 67F12 bind to the same or overlapping epitopes on an 80 Kd antigen indiCated as MAM-5. On frozen as well as on formalin-fixed lactating mammary gland sections, a very strong reaction in secretion products is observed. Occasionally, preexisting ducts react in some of the mammary tumors, indiCating an enhanced secretory activity in these parts of the mammary gland.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Target Information
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe; neutrophil lactoferrin; Talalactoferrin
Gene Aliases: Csp82; GIG12; HEL110; HLF2; LF; LTF; MMS10R; Ms10r
UniProt ID: (Human) E7EQH5, (Mouse) P08071
Entrez Gene ID: (Human) 4057, (Mouse) 17002
ossification
regulation of cytokine production
retina homeostasis
innate immune response in mucosa
transcription, DNA-templated
proteolysis
ion transport
humoral immune response
antibacterial humoral response
antifungal humoral response
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor production
negative regulation of ATPase activity
iron assimilation by chelation and transport
positive regulation of osteoblast proliferation
positive regulation of toll-like receptor 4 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular protein metabolic process
negative regulation by host of viral process
negative regulation of viral genome replication
cell redox homeostasis
positive regulation of osteoblast differentiation
negative regulation of viral process
positive regulation of NF-kappaB transcription factor activity
bone morphogenesis
positive regulation of protein serine/threonine kinase activity
positive regulation of bone mineralization involved in bone maturation
negative regulation of single-species biofilm formation in or on host organism
positive regulation of chondrocyte proliferation
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
negative regulation of osteoclast development
immune system process
transport
iron ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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