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Invitrogen
Lassa virus RING finger protein Z Polyclonal Antibody
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FIGURE: 1 / 1
Lassa virus RING finger protein Z Antibody (PA5-112046) in WB
Western Blot analysis of Lassa virus RING finger protein Z in non-transfected (–) and transfected (+) 293T whole cell extract. Sample was separated with 15% SDS-PAGE, incubated with polyclonal antibody (Product # PA5-112046) at a dilution of 1:5,000, and followed by HRP-conjugated anti-rabbit IgG.
Product Details
PA5-112046
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of Lassa virus RING finger protein Z (Lassa virus (strain mouse/Sierra Leone/Josiah/1976)). The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.11 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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