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Bioss
Layilin Polyclonal Antibody
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FIGURE: 1 / 3
Layilin Antibody (BS-4629R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse intestines; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Layilin) Polyclonal Antibody, Unconjugated (bs-4629R) at 1:400 overnight at 4°C, followed by a conjugated secondary (Goat Anti-rab... View More
Product Details
BS-4629R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Layilin, amino acids 281-382.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Layilin is a cell surface receptor encoded by the LAYN gene, known for its involvement in cell adhesion and motility processes. It is a member of the C-type lectin-like domain protein family and plays a crucial role in mediating interactions with the extracellular matrix. Layilin is associated with cytoskeletal reorganization, impacting cellular processes such as shape change, migration, and stabilization of cell-matrix contacts. It has been shown to interact with other proteins like talin, contributing to the linkage between the cell membrane and the actin cytoskeleton, which is vital for maintaining cell structure and facilitating movement. Layilin's role in cell adhesion and motility makes it significant in developmental processes and wound healing. Additionally, dysregulation of layilin expression has been implicated in cancer metastasis, where altered adhesive properties and increased motility contribute to tumor progression and dissemination. Research is ongoing to explore the detailed mechanisms of layilin's function and its potential as a target for therapeutic intervention in diseases characterized by abnormal cell migration and adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ30977; FLJ31092; Layilin; LYAN
Gene Aliases: E030012M19Rik; Gm511; LAYN; RGD1564444; UNQ208/PRO234
UniProt ID: (Human) Q6UX15, (Mouse) Q8C351
Entrez Gene ID: (Human) 143903, (Rat) 500996, (Mouse) 244864
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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