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Rockland
Ldb2 Polyclonal Antibody
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FIGURE: 1 / 2
Ldb2 Antibody (600-401-459) in IHC (P)
Rocklands Affinity Purified anti-LDB2 (Clim1) antibody was used at a 5 µg/ml to detect LDB2 in human brain cortex tissue. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Tissue was formalin-fixed and paraffin embedded.
Product Details
600-401-459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chicken,
Chimpanzee,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near aa 100-125 of Mouse LDB2.
Conjugate
Form
Liquid
Concentration
1.06 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against mouse LDB2. A BLAST analysis was used to suggest reactivity with this protein from mouse, human, chimpanzee, dog, rat and chicken based on 100% homology for the immunogen sequence. Cross reactivity with LDB2 homologues from other sources has not been determined.
Target Information
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins. These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes. The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 and Clim2/Lbd1/Nli; and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Carboxyl-terminal LIM domain-binding protein 1; cLdb2; CLIM-1; LDB-2; LDB1; LIM binding domain 2; LIM domain binding protein CLIM-1; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; LIM domain-binding protein 2; unnamed protein product
Gene Aliases: AI035351; AW146358; CLIM-1; CLIM1; CLP-36; LDB-2; LDB1; LDB2; Ldb3
UniProt ID: (Human) O43679, (Chicken) Q9W676, (Mouse) O55203
Entrez Gene ID: (Human) 9079, (Dog) 479084, (Chicken) 395631, (Rat) 289664, (Mouse) 16826
negative regulation of transcription from RNA polymerase II promoter
hair follicle development
nervous system development
epithelial structure maintenance
regulation of cell migration
somatic stem cell population maintenance
regulation of kinase activity
positive regulation of cellular component biogenesis
positive regulation of transcription from RNA polymerase II promoter
biological_process
negative regulation of transcription, DNA-templated
regulation of nucleic acid-templated transcription
regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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