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Bethyl Laboratories
Leo1 Polyclonal Antibody
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Product Details
IHC-00573
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 550 and 600 of human senescence downregulated leo1-like.
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Chinese hamster
Target Information
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leo1 Paf1/RNA polymerase II complex component; Leo1, Paf1/RNA polymerase II complex component, homolog; RDL; Replicative senescence down-regulated leo1-like protein; RNA polymerase-associated protein LEO1; unnamed protein product
Gene Aliases: Gm185; LEO1; RDL
UniProt ID: (Human) Q8WVC0, (Mouse) Q5XJE5
Entrez Gene ID: (Human) 123169, (Mouse) 235497
endodermal cell fate commitment
transcription elongation from RNA polymerase II promoter
Wnt signaling pathway
stem cell population maintenance
mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA polyadenylation
histone monoubiquitination
positive regulation of mRNA 3'-end processing
histone H2B ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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