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Invitrogen
Leptin Receptor Polyclonal Antibody
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Product Details
PA5-120844
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1070-1165 of human LEPR (NP_0022942)
Conjugate
Form
Liquid
Concentration
0.76 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: Rat lung, Rat liver. The target is usually found in the following locations: Cell membrane, Secreted, Single-pass type I membrane protein.
Immunogen sequence: ENNDKKSIYY LGVTSIKKRE SGVLLTDKSR VSCPFPAPCL FTDIRVLQDS CSHFVENNIN LGTSSKKTFA SYMPQFQTCS TQTHKIMENK MCDLTV
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD295; CD295; CD295 antigen; HuB219; HuB219.2; LEP-R; Leptin receptor; Leptin receptor (fatty); OB receptor; OB-R
Gene Aliases: CD295; DB; Fa; LEP-R; LEPR; LEPRD; OB-R; OBR
UniProt ID: (Human) P48357, (Rat) Q62959
Entrez Gene ID: (Human) 3953, (Rat) 24536
angiogenesis
energy reserve metabolic process
cell surface receptor signaling pathway
multicellular organism development
cholesterol metabolic process
negative regulation of autophagy
sexual reproduction
T cell differentiation
leptin-mediated signaling pathway
glucose homeostasis
response to leptin
negative regulation of gluconeogenesis
regulation of bone remodeling
negative regulation of hydrolase activity
regulation of feeding behavior
energy homeostasis
bone growth
regulation of energy homeostasis
ovulation from ovarian follicle
response to hypoxia
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway
female pregnancy
response to nutrient
cytokine-mediated signaling pathway
response to nicotine
eating behavior
positive regulation of MAPK cascade
response to estrogen
cellular response to organic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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