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Invitrogen
Leptin Receptor Polyclonal Antibody
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FIGURE: 1 / 10
Leptin Receptor Antibody (PA5-18522) in IHC (P)
Immunohistochemistry analysis of Leptin Receptor in human liver. Samples were incubated with Leptin Receptor polyclonal antibody (Product # PA5-18522) using a dilution of 4 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18522
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (TQDDIEKHQSDAG) corresponding to the internal amino acids of LEPR (aa 829-841).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with canine based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD antigen CD295; CD295; CD295 antigen; cytokine receptor; HuB219; HuB219.2; LEP-R; Leptin receptor; OB receptor; OB-R; splice variant form 12.1; Ob receptor; splice variant form 13.2; Ob receptor; splice variant form 6.4; Ob receptor; unnamed protein product
Gene Aliases: CD295; DB; LEP-R; LEPR; LEPRD; OB-R; OBR
UniProt ID: (Human) P48357
Entrez Gene ID: (Human) 3953
angiogenesis
glycogen metabolic process
gluconeogenesis
energy reserve metabolic process
phagocytosis
cell surface receptor signaling pathway
multicellular organism development
cholesterol metabolic process
positive regulation of cell proliferation
negative regulation of autophagy
glial cell proliferation
cytokine-mediated signaling pathway
sexual reproduction
T cell differentiation
leptin-mediated signaling pathway
glucose homeostasis
response to leptin
negative regulation of gluconeogenesis
regulation of bone remodeling
system development
regulation of transport
regulation of feeding behavior
energy homeostasis
receptor signaling pathway via STAT
bone growth
positive regulation of cold-induced thermogenesis
transport across blood-brain barrier
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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