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Lincomycin is a naturally occurring antibiotic produced by the actinomycete Streptomyces lincolnensis, effective against Gram-positive bacteria and protozoans. It was first isolated in Lincoln, Nebraska, and belongs to the lincosamide group of antibiotics, characterized by a chemical structure consisting of amino acid and sugar moieties. The biosynthesis of lincomycin involves the creation of an unusual eight-carbon aminosugar, which is then functionalized with diverse l-proline derivatives and sulfur appendages. The MarR family transcriptional regulator LcbR2 has been identified as an activator of lincomycin biosynthesis, enhancing its production. Lincomycin A and its semisynthetic analogue, clindamycin, are used in clinical settings due to their unique structures and remarkable biological activities.
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