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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues I(19) Q Q V S S Q D L S(28)C of human Lubricin.|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA3-130 detects lubricin in human samples.
PA3-130 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~64 kDa protein representing lubricin in human samples.
The PA3-130 immunogen is a synthetic peptide corresponding to residues I(19) Q Q V S S Q D L S(28)C of human Lubricin. This polyclonal antibody has been referred to as: JSCIQQ. This peptide (Cat. # PEP-288) is available for use in neutralization and control experiments.
Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
articular superficial zone protein; hemangiopoietin; lubricin; Megakaryocyte stimulating factor; PRG4; Proteoglycan-4; superficial zone proteoglycan
CACP; HAPO; JCAP; MSF; PRG4; SZP