|Tested species reactivity||Dog, Cat, Human, Non-human primate, Pig|
|Published species reactivity||Pig, Mouse, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Human lysozyme purified from the urine of patients with monocytic leukemia|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16668 targets Lysozyme in IHC (P) applications and shows reactivity with Canine, Feline, Human, Non-human primate, and Porcine samples.
The PA5-16668 immunogen is human lysozyme purified from the urine of patients with monocytic leukemia.
Lysozyme is synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
PA5-16668 was used in immunohistochemistry - paraffin section to characterize the enhancement of tumorigenicity and stemness of intestinal progenitors due to a high-fat diet
|Beyaz S,Mana MD,Roper J,Kedrin D,Saadatpour A,Hong SJ,Bauer-Rowe KE,Xifaras ME,Akkad A,Arias E,Pinello L,Katz Y,Shinagare S,Abu-Remaileh M,Mihaylova MM,Lamming DW,Dogum R,Guo G,Bell GW,Selig M,Nielsen GP,Gupta N,Ferrone CR,Deshpande V,Yuan GC,Orkin SH,Sabatini DM,Yilmaz ÖH||Nature (531:53)||2016|
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
PA5-16668 was used in immunohistochemistry - paraffin section to characterize intestinal tuft cells
|Gerbe F,van Es JH,Makrini L,Brulin B,Mellitzer G,Robine S,Romagnolo B,Shroyer NF,Bourgaux JF,Pignodel C,Clevers H,Jay P||The Journal of cell biology (192:767)||2011|
Characterization of antigen-presenting cells from the porcine respiratory system.
PA5-16668 was used in flow cytometry to describe the phenotypic and functional properties of porcine APCs in the lung , mediastinal lymph node, and bronchoalveolar lavage cells
|López-Robles G,Silva-Campa E,Burgara-Estrella A,Hernández J||Research in veterinary science (100:80)||2015|
The CSF-1 receptor fashions the intestinal stem cell niche.
PA5-16668 was used in immunocytochemistry and immunohistochemistry to study the role of CSF-1R in the maturation of Paneth cells and maintenance of the intestinal stem cell niche
|Akcora D,Huynh D,Lightowler S,Germann M,Robine S,de May JR,Pollard JW,Stanley ER,Malaterre J,Ramsay RG||Stem cell research (10:203)||2013|
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
PA5-16668 was used in immunohistochemistry to study the role of Paneth cell mTORC1 in mediating the effects of caloric restriction on intestinal stem cells
|Yilmaz ÖH,Katajisto P,Lamming DW,Gültekin Y,Bauer-Rowe KE,Sengupta S,Birsoy K,Dursun A,Yilmaz VO,Selig M,Nielsen GP,Mino-Kenudson M,Zukerberg LR,Bhan AK,Deshpande V,Sabatini DM||Nature (486:490)||2012|