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Invitrogen
IL-13 Monoclonal Antibody (5A2)
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Product Details
M130
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rat
/ IgG
Class
Monoclonal
Type
Antibody
Clone
5A2
Immunogen
Recombinant human IL-13
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
500 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is specific for natural and recombinant IL-13. The unlabeled version of this antibody does not perform as a detection antibody with secondary reagents in Western blot, however the biotinylated version, Product # M130B, was successfully tested as a detection antibody in a sandwich ELISA with Product # P130E.
Endotoxin level <0.52 EU/mg.
This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).
Target Information
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALRH; ALRH antibody; BHR1; il 13; ILN; Interleukin; Interleukin13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600 antibody
Gene Aliases: IL-13; P600
UniProt ID: (Human) P35225
Entrez Gene ID: (Human) 3596
microglial cell activation
positive regulation of immunoglobulin production
apoptotic process
inflammatory response
immune response
JAK-STAT cascade
response to mechanical stimulus
regulation of proton transport
positive regulation of gene expression
positive regulation of B cell proliferation
response to lipopolysaccharide
positive regulation of interleukin-10 production
transforming growth factor beta1 production
regulation of transforming growth factor beta1 production
response to nicotine
interleukin-13-mediated signaling pathway
macrophage activation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of macrophage activation
positive regulation of ion transport
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of protein secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of release of sequestered calcium ion into cytosol
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
negative regulation of transforming growth factor beta production
positive regulation of cold-induced thermogenesis
negative regulation of lung ciliated cell differentiation
positive regulation of lung goblet cell differentiation
negative regulation of complement-dependent cytotoxicity
positive regulation of pancreatic stellate cell proliferation
negative regulation of endothelial cell apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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