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Invitrogen
eIF2b gamma Monoclonal Antibody (1H3)
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FIGURE: 1 / 11
eIF2b gamma Antibody (MA1-078) in ICC/IF
Immunofluorescent analysis of eIF2B3 (green) showing staining in the cytoplasm of COS7 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with an eIF2B3 monoclonal antibody (Product # MA1-078) in 3% BSA-PBS at a di... View More
Product Details
MA1-078
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1H3
Immunogen
Full length human eIF2B3 produced in HEK293T cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 1mg/mL BSA, 30% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-078 detects eIF2B3 in human, non-human primate and rat samples and has been successfully used in Western blot, ICC/IF, IHC (P) and immunoprecipitation applications.
The immunogen for MA1-078 is full length human eIF2B3 produced in HEK293T cells.
Target Information
EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2B GDP-GTP exchange factor subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma; EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); eukaryotic translation initiation factor 2B, subunit 3 gamma; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; eukaryotic translation initiation factor EIF2Bgamma; guanine nucleotide exchange factor; translation initiation factor eIF-2B subunit gamma; Translation initiation factor eIF2B subunit gamma; unnamed protein product
Gene Aliases: EIF-2B; EIF2B3; Eif2bg; EIF2Bgamma; VWM3
UniProt ID: (Human) Q9NR50, (Rat) P70541
Entrez Gene ID: (Human) 8891, (Rat) 171145
cytoplasmic translational initiation
translation
translational initiation
central nervous system development
response to heat
response to glucose
oligodendrocyte development
response to peptide hormone
T cell receptor signaling pathway
regulation of translation
negative regulation of translational initiation in response to stress
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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