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ICAM-1 Monoclonal Antibody (MEM-111), PE

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View all (151) ICAM-1 (CD54) antibodies

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ICAM-1 Monoclonal Antibody (MEM-111), PE

Product Details

MA1-10249

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

20 µL/1x10^6 cells
View 3 publications 3 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Bovine, Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

MEM-111

Immunogen

Raji human Burkitt's lymphoma cell line
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11151852

Product Specific Information

This antibody reacts with an extracellular epitope of CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation; it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD54; cell surface glycoprotein P3.58; epididymis secretory sperm binding protein; Human rhinovirus receptor; ICAM-1; ICAM-1 soluble variant; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; intercellular adhesion molecule-1 precursor; Ly 47; Major group rhinovirus receptor; major group rhinovirus receptor precusor; MALA2; sCD54; soluble CD54; Surface antigen of activated B cells; unnamed protein product

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Gene Aliases: BB2; CD54; ICAM; ICAM1; P3.58

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UniProt ID: (Human) P05362, (Bovine) Q95132, (Rat) Q00238

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Entrez Gene ID: (Human) 3383, (Bovine) 281839, (Rat) 25464

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Function(s)
virus receptor activity transmembrane signaling receptor activity integrin binding protein binding signaling receptor activity protein complex binding
Process(es)
ovarian follicle development response to hypoxia response to amphetamine T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation cell adhesion leukocyte cell-cell adhesion cell aging sensory perception of sound regulation of cell shape response to ionizing radiation response to sulfur dioxide response to organic cyclic compound single organismal cell-cell adhesion membrane to membrane docking regulation of cell adhesion positive regulation of actin filament polymerization cellular response to nutrient levels response to lipopolysaccharide cell adhesion mediated by integrin response to gonadotropin response to drug response to amino acid positive regulation of GTPase activity adhesion of symbiont to host positive regulation of nitric oxide biosynthetic process response to ethanol positive regulation of vasoconstriction response to copper ion receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to organic substance cellular response to alkaloid cellular response to glucose stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia establishment of Sertoli cell barrier regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process regulation of leukocyte mediated cytotoxicity immune effector process immune response heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules viral entry into host cell T cell extravasation cell-cell adhesion cellular response to oxygen-containing compound cellular response to beta-amyloid cellular response to leukemia inhibitory factor
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