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MA1-10826 detects Factor V, light chain, from human samples.
MA1-10826 has been successfully used in ELISA and immunohistochemistry applications.
The MA1-10826 immunogen is purified human Factor V.
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activated protein C cofactor; Coagulation factor V; coagulation factor V (proaccelerin, labile factor); coagulation factor V jinjiang A2 domain; factor V Leiden; Proaccelerin, labile factor
Gene Aliases: F5; FVL; PCCF; RPRGL1; THPH2
UniProt ID: (Human) P12259
Entrez Gene ID: (Human) 2153
Molecular Function: oxidase oxidoreductase
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