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Invitrogen

BID Monoclonal Antibody (23F7)

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BID Monoclonal Antibody (23F7)

Product Details

MA1-13043

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

23F7

Immunogen

Residues 5-195 from human recombinant protein expressed in bacteria
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985736

Product Specific Information

MA1-13043 detects BID from human and mouse samples.



MA1-13043 has been successfully used in ICC/IF and Western blot procedures. By Western blot, this antibody detects a 22 kDa protein corresponding to human BID.



The MA1-13043 antigen is a recombinant protein corresponding to residues 5-195 of human BID.

Target Information

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apoptic d; apoptic death agonist; BH3-interacting domain death agonist; BID; desmocollin type 4; HGNC:1050; Human BID coding sequence; MGC15319; MGC42355; OTTHUMP00000196197; p22 BID; unnamed protein product

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Gene Aliases: 2700049M22Rik; AI875481; AU022477; BID; FP497

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UniProt ID: (Human) P55957, (Mouse) P70444

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Entrez Gene ID: (Human) 637, (Mouse) 12122

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Function(s)
death receptor binding protein binding ubiquitin protein ligase binding cysteine-type endopeptidase regulator activity involved in apoptotic process
Process(es)
release of cytochrome c from mitochondria protein targeting to mitochondrion apoptotic process extrinsic apoptotic signaling pathway via death domain receptors apoptotic mitochondrial changes positive regulation of mitochondrial membrane potential positive regulation of protein complex assembly cellular response to stress intracellular signal transduction regulation of T cell proliferation signal transduction in response to DNA damage mitochondrial ATP synthesis coupled electron transport regulation of apoptotic process positive regulation of apoptotic process regulation of epithelial cell proliferation neuron apoptotic process protein-containing complex assembly establishment of protein localization to membrane positive regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway hepatocyte apoptotic process mitochondrial outer membrane permeabilization fibril organization regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intracellular signal transduction regulation of G1/S transition of mitotic cell cycle positive regulation of fibroblast apoptotic process regulation of apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of protein oligomerization positive regulation of protein oligomerization positive regulation of protein homooligomerization regulation of cell proliferation protein homooligomerization
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