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Invitrogen
Separase Monoclonal Antibody (XJ11-1B12)
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Product Details
MA1-16595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
XJ11-1B12
Immunogen
Maltose-Binding Protein fusion of a C-terminal fragment of human Separase (residues 1866-1996).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Amount
90 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This Separase (XJ11-1B12) antibody is useful for Western Blot, where a band is seen at ~220 kDa (full-length form) and ~65 kDa (auto-processed form).
Target Information
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Caspase-like protein ESPL1; cysteine protease; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; Extra spindle poles-like 1 protein; FLJ46492; KIAA0165; Separase; Separin; separin, cysteine protease; unnamed protein product
Gene Aliases: ESP1; ESPL1; KIAA0165; SEPA
UniProt ID: (Human) Q14674
Entrez Gene ID: (Human) 9700
mitotic sister chromatid segregation
meiotic spindle organization
mitotic cell cycle
nuclear division
mitotic cytokinesis
proteolysis
apoptotic process
chromosome segregation
meiosis I
establishment of mitotic spindle localization
homologous chromosome segregation
positive regulation of mitotic metaphase/anaphase transition
negative regulation of sister chromatid cohesion
mitotic sister chromatid separation
meiotic chromosome separation
nuclear chromosome segregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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