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Invitrogen
S-arrestin Monoclonal Antibody (PDS-1)
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FIGURE: 1 / 2
S-arrestin Antibody (MA1-16962) in IHC (P)
Immunohistochemistry analysis of S-arrestin in immersion fixed paraffin-embedded sections of human prostate cancer. Samples were incubated with S-arrestin monoclonal antibody (Product # MA1-16962) using a dilution of 1:300 for 1 hour at room temperature followed by Anti-Mouse IgG VisUCyte HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining... View More
Product Details
MA1-16962
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
PDS-1
Immunogen
Porcine retinal S-arrestin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: retina lysate.
Target Information
S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 48 kDa protein; arrestin 1; arrestin-1; arrestin1; DKFZp686D1084; DKFZp686I1383; photoreceptor protein/alleged cGMP phosphodiesterase activation modulator; retinal S antigen; Retinal S-antigen; retinal S-antigen (48 KDa protein); rod arrestin; Rod photoreceptor arrestin; S-AG; S-antigen; S-antigen; retina and pineal gland (arrestin); S-arrestin; unnamed protein product
Gene Aliases: RP47; RP96; S-AG; SAG
UniProt ID: (Pig) P79260, (Bovine) P08168, (Human) P10523
Entrez Gene ID: (Pig) 397151, (Bovine) 280922, (Human) 6295
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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