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Invitrogen
NGFR Monoclonal Antibody (ME20.4), FITC
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Product Details
MA1-18420
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Sheep,
Pig,
Rabbit
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ME20.4
Immunogen
Human WM245 melanoma cells.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody conjugate can be stored at 4 °C for up to 4 months with the addition of appropriate antibacterial agent.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD271 antigen; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; unnamed protein product
Gene Aliases: CD271; Gp80-LNGFR; NGR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Pig) 100525607, (Human) 4804, (Sheep) 101119064, (Dog) 491071, (Rabbit) 100349095
beta-amyloid binding
transmembrane signaling receptor activity
death receptor activity
protein binding
calmodulin binding
coreceptor activity
small GTPase binding
ubiquitin protein ligase binding
signaling receptor activity
neurotrophin binding
nerve growth factor binding
transmembrane signal receptor
cellular glucose homeostasis
intracellular protein transport
signal transduction
Rho protein signal transduction
circadian rhythm
negative regulation of cell migration
circadian regulation of gene expression
dorsal aorta development
regulation of cell proliferation
glucose homeostasis
positive regulation of apoptotic process
neuron apoptotic process
extrinsic apoptotic signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of protein localization to nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cellular response to beta-amyloid
positive regulation of endothelial cell apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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