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Invitrogen
hnRNP A1 Monoclonal Antibody (9H10)
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FIGURE: 1 / 6
hnRNP A1 Antibody (MA1-26736) in ICC/IF
Immunofluorescence analysis of hnRNP A1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with hnRNP A1 Monoclonal Antibody (9H10) (Product # MA1-26736) at 5 microgram/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A... View More
Product Details
MA1-26736
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Published species
Hamster,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
9H10
Immunogen
Purified human hnRNP-A1.
Conjugate
Form
Liquid
Concentration
2.2 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T.
A band of approximately 34 kDa is detected by Western Blot.
Target Information
HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; HDP; HDP-1; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP I; HNRNP-I; HNRNPI; HNRPA1MGC102835; HNRPI; MGC102835; nuclear ribonucleoprotein particle A1 protein; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; putative heterogeneous nuclear ribonucleoprotein A1-like 3; Putative heterogeneous nuclear ribonucleoprotein A1-like protein 3; RP11-78J21.1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed; unnamed protein product; Unwinding protein 1; UP1
Gene Aliases: ALS19; ALS20; Fli-2; Hdp; HDP-1; hnRNP A1; hnRNP-A1; HNRNPA1; HNRPA1; HNRPA1L3; I79_022927; IBMPFD3; MPD3; Tis; UP 1
UniProt ID: (Bovine) P09867, (Human) P09651, (Mouse) P49312, (Rat) P04256
Entrez Gene ID: (Bovine) 505093, (Dog) 102152026, (Human) 3178, (Chinese hamster) 100769923, (Mouse) 15382, (Rat) 29578
miRNA binding
nucleic acid binding
DNA binding
single-stranded DNA binding
RNA binding
single-stranded RNA binding
mRNA 3'-UTR binding
protein binding
protein domain specific binding
pre-mRNA binding
identical protein binding
telomeric repeat-containing RNA binding
G-rich strand telomeric DNA binding
nucleotide binding
poly(A) RNA binding
mRNA processing
RNA splicing
mRNA transport
cellular response to sodium arsenite
alternative mRNA splicing, via spliceosome
transport
RNA metabolic process
nuclear export
nuclear import
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
RNA export from nucleus
negative regulation of telomere maintenance via telomerase
positive regulation of telomere maintenance via telomerase
cellular response to glucose starvation
regulation of RNA splicing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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