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Invitrogen
MRP3 Monoclonal Antibody (M3II-21)
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Product Details
MA1-35679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
M3II-21
Immunogen
MRP3 aa 830-949
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant with 0.7% BSA
Contains
0.1% sodium azide
Storage conditions
2-8°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody reacts with an internal epitope of MRP3, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M3II-21 was raised against a bacterial fusion protein of MRP3, containing amino acids 830-949 of the protein. M3II-21 does not cross-react with the human MDR1, MRP1, MRP2 or MRP5 gene products. M3II-21 has potential value for detection of MRP3-mediated drug-resistance in human tumor samples.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; Canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; cMOAT2/MRP3; DKFZp686E22157; homolog of the multidrug resistance-associated protein MRP1; MOAT-D; MRP transporter family; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter D; multidrug resistance associated protein; Multidrug resistance-associated protein 3; similar to multidrug resistance protein MRP3
Gene Aliases: ABC31; ABCC3; CMOAT2; EST90757; MLP2; MOAT-D; MRP3
UniProt ID: (Human) O15438
Entrez Gene ID: (Human) 8714
nucleotide binding
ATP binding
xenobiotic-transporting ATPase activity
glucuronoside transmembrane transporter activity
glutathione S-conjugate-exporting ATPase activity
bile acid-exporting ATPase activity
ATPase activity
transmembrane transporter activity
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
anion transmembrane-transporting ATPase activity
icosanoid transmembrane transporter activity
ABC-type transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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