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Invitrogen
MBL2 Monoclonal Antibody (3E7)
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FIGURE: 1 / 4
MBL2 Antibody (MA1-40145) in Flow
Science advances 2023 -
Fig. 2. MBL and hItln1 binding to microbial populations in human stool samples. ( A ) Schematic of flow cytometry-based assay to measure soluble lectin binding to stool microbiome. ( B ) Flow cytometry analysis of healthy human stool plotted as SYTO BC against lectin binding (anti-Strep DY649). Panels show no lectin control (column 1), and strep-MBL (top row), or strep-hItln1 (bottom row) binding in the pre... View More
Product Details
MA1-40145
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Rhesus monkey,
Yeast
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E7
Immunogen
Serum isolated human RaRF
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-40145 detects MBL from human samples.
The MA1-40145 immunogen is Mannose Binding Lectin (MBL).
MA1-40145 has been successfully used in flow cytometry, Western blot, ELISA, Functional Assays, and immunohistochemistry (frozen) applications.
Negative control: Nonimmune normal serum or TBS.
Endotoxin <24 EU/mg.
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activates complement system; Collectin-1; Collectin1; mannan-binding lectin; Mannan-binding protein; Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; MBP-C; MBP1; MBPC; MGC116832; MGC116833
Gene Aliases: COLEC1; HSMBPC; MBL; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD
UniProt ID: (Human) P11226
Entrez Gene ID: (Human) 4153
complement activation, lectin pathway
activation of membrane attack complex
immune system process
cell surface pattern recognition receptor signaling pathway
proteolysis
acute-phase response
complement activation
complement activation, classical pathway
response to oxidative stress
opsonization
zymogen activation
killing of cells of other organism
defense response to bacterium
surfactant homeostasis
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
protein maturation
killing by host of symbiont cells
antiviral innate immune response
positive regulation of opsonization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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