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Invitrogen
C1q Monoclonal Antibody (JL-1), FITC
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Product Details
MA1-40313
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
JL-1
Immunogen
Purified Mouse C1q
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-40313 detects C1q from mouse, rat, and human samples.
MA1-40313 has been successfully used in immunofluorescence, immunohistochemistry (frozen), ELISA, functional assays and Western blot applications.
The MA1-40313 immunogen is Purified Mouse C1q.
Positive control: Spleen and kidney tissue of wild-type mice; Negative control: Spleen and kidney tissue of C1q -/- mice
Target Information
C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: complement 1-q subcomponent beta-chain; complement C1q chain A; complement C1q chain B; Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, c polypeptide; complement component 1, q subcomponent, gamma polypeptide; complement component C1q, A chain; complement component C1q, B chain; complement subcomponent C1q chain B; unnamed protein product
Gene Aliases: AI255395; AI385742; C1q; C1Q-C; C1QA; C1QB; C1QC; C1QD1; C1QD2; C1QD3; C1QG; Ciqc
UniProt ID: (Human) P02745, (Human) P02746, (Human) P02747, (Rat) P31720, (Mouse) P98086, (Mouse) P14106, (Rat) P31721, (Rat) P31722, (Mouse) Q02105
Entrez Gene ID: (Human) 712, (Human) 713, (Human) 714, (Rat) 298566, (Mouse) 12259, (Mouse) 12260, (Rat) 29687, (Rat) 362634, (Mouse) 12262
complement activation, classical pathway
biological_process
innate immune response
microglial cell activation
immune system process
complement activation
cell-cell signaling
neuron remodeling
astrocyte activation
synapse organization
synapse pruning
complement-mediated synapse pruning
vertebrate eye-specific patterning
inner ear development
negative regulation of granulocyte differentiation
negative regulation of macrophage differentiation
immune response
brain development
aging
response to organic substance
response to glucocorticoid
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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