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Invitrogen
CDw17 Monoclonal Antibody (B392 (HuLy-m13))
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Product Details
MA1-91271
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
B392 (HuLy-m13)
Immunogen
Immunoprecipitated complexes of human detergent PBL lysate and anti-b2m proteins.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Tonsil, Lymph Node, Granulocytes, Platelets.
Target Information
CDw17, also known as Lactosylceramide (LacCer) or CD17, is a glycosphingolipid present on the surface of various cell types, including leukocytes, erythrocytes, and endothelial cells. It serves as a significant component of the cell membrane, involved in cell-cell interactions, cell adhesion, and signal transduction. Lactosylceramide is synthesized by the enzyme B-1,4-galactosyltransferase, which adds a galactose molecule to glucosylceramide. It acts as a precursor for more complex glycosphingolipids, playing critical roles in numerous physiological processes and immune responses. CDw17 is implicated in several pathological conditions, including atherosclerosis, cancer, and inflammatory diseases. In cancer, CDw17 acts as a mediator for tumor cell adhesion, invasion, and metastasis, making it a potential target for therapeutic intervention. Additionally, due to its role in the immune system, modulation of Lactosylceramide levels can influence immune cell functions and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD17; Lactosylceramide
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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