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Invitrogen
RXRB Monoclonal Antibody (MOK13-17)
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FIGURE: 1 / 13
RXRB Antibody (MA3-812) in IHC
Diabetes 2010 -
FIG. 2. Islet-specific induction of RXRbetaDeltaC2 in the Ins-rtTA/TetO-RXRbetaDeltaC2 double-Tg mice. The total RNA of the pancreas and other organs was subjected to RT-PCR analyses. The rtTA transgene expression was detected only in the pancreas samples from three different Tg mice and not in the other organs or in the non-Tg pancreas ( A , upper panel ). Hypoxanthine-guanine phosphoribosyltransferase (HP... View More
Product Details
MA3-812
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MOK13-17
Immunogen
Recombinant human retinoic X receptor beta protein.
Conjugate
Form
Liquid
Amount
100 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
Product Specific Information
MA3-812 detects retinoid X receptor (RXR) beta from human and mouse tissues. This antibody is specific for the RXR beta isoform and does not cross react with either RXR alpha or gamma.
MA3-812 has been successfully used in Western blot, immunofluorescence, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~50 kDa protein representing RXR beta from transfected Sf9 cells. Immunofluorescence staining of RXR beta in MCF-7 cells overexpressing RXR beta with MA3-812 results in strong nuclear staining. Gel super shift experiments show disruption of vitamin D receptor (VDR)/RXR beta/VDRE (DNA) complex formation when RXR beta was preincubated with MA3-812, yet experiments using THR showed a supershift of the thyroid hormone receptor (THR)/RXR beta heterodimer by this product.
The MA3-812 antigen is recombinant human RXR beta.
Target Information
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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