Search
Invitrogen
OATP2/OATP8 Monoclonal Antibody (MDQ)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
OATP2/OATP8 Antibody (MA3-935) in ICC/IF
Immunofluorescent analysis of OATP8 in HepG2 Cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a OATP8 monoclonal antibody (Product # MA3-935) at a dilution of 1:20 overnight at 4 C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product # 35503). OATP8 staining (green), F-Actin staining with ... View More
Product Details
MA3-935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MDQ
Immunogen
Synthetic peptide corresponding to residues M(1) D Q N Q H L N K T A E A Q P S E N K K T R Y(23) C of human OATP2.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA3-935 detects OATP8 from human tissue and cells. This antibody does not detect dog, mouse or rat protein. MA3-935 also detects the OATP2 isoform.
MA3-935 has been successfully used in immunohistochemistry, immunofluorescence and immunoprecipitation procedures. Immunofluorescence staining of OATP8 in human liver samples results in a pattern consistent with plasma membrane staining.
The MA3-935 immunogen is a synthetic peptide corresponding ot residues M(1) D Q N Q H L N K T A E A Q P S E N K K T R Y(23) C of human OATP2.
Target Information
The OATPs (organic anion transporter polypeptides) are a family of transport proteins that have been found to mediate the uptake of organic ions into hepatocyte cells. These proteins fall into the solute carrier family 21A (SLC21A), and are expressed in liver, kidney, and brain. These polypeptides are involved in the excretion of potentially toxic compounds and therefore play a role in the overall detoxification system of the body. Unlike other members of the OATP family, OATP2 and 8 have been detected exclusively in the liver, and there is an 80% amino acid sequence homology between these polypeptides. Other names for OATP2 include SLC21A6, OATP-C, and LST-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Liver-specific organic anion transporter 1; Liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; LST-1; LST-2; LST-3c; LST-3TM13; membrane transporter; OATP-2; OATP-8; OATP-C; OATP1B3; OATP2; OATP transporter family member; Organic anion transporter 8; organic anion transporter LST-3c; Organic anion transporter SLC21A6; Organic anion-transporting polypeptide 8; SLCO1B1; Sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; solute carrier family 21 (organic anion transporter), member 8; Solute carrier family 21 member 6; Solute carrier family 21 member 8; Solute carrier organic anion transporter family member 1B1; Solute carrier organic anion transporter family member 1B3; unnamed protein product
Gene Aliases: HBLRR; LST-1; LST-2; LST-3TM13; LST1; LST2; LST3; OATP-8; OATP-C; OATP1B1; OATP1B3; OATP2; OATP8; OATPC; SLC21A6; SLC21A8; SLCO1B1; SLCO1B3
UniProt ID: (Human) Q9Y6L6, (Human) Q9NPD5
Entrez Gene ID: (Human) 10599, (Human) 28234
organic anion transmembrane transporter activity
bile acid transmembrane transporter activity
prostaglandin transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
thyroid hormone transmembrane transporter activity
transmembrane transporter activity
serine-type endopeptidase inhibitor activity
peptidase inhibitor activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support