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Invitrogen
H3K27me2 Monoclonal Antibody (T.213.4)
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FIGURE: 1 / 1
H3K27me2 Antibody (MA5-11197) in WB
Annals of medicine 2021 -
Figure 2. Western blotting of global histone modifications on H3 protein in colon cancerous tissue and paired adjacent non-cancerous tissue. A, six post-translational modifications (H3K4me2, K9me2, K9me, K9ac, K27me2 and K27ac) were measured. beta-actin was used as a control. Total H3 was used to validate extraction procedure. The number under each pair of bands in the blots showed relative expression ratio... View More
Product Details
MA5-11197
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
T.213.4
Immunogen
Synthetic peptide corresponding to the amino terminus of histone H3 in which Lys27 is di-methylated
Conjugate
Form
Liquid
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with mono-methylated, di-methylated or tri-methylated histone H3 Lys4, Lys9, Lys36 or histone H4 Lys20.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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