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Invitrogen
TPM1 Monoclonal Antibody (CH1)
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Product Details
MA5-11783
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Rat
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
CH1
Immunogen
Tropomyosin protein purified from chicken embryo fibroblasts (CEF) and chicken leg, heart, and gizzard
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-11783 targets Tropomyosin in IF and IHC (P) applications and shows reactivity with Chicken, Human, and Rat samples.
The MA5-11783 immunogen is tropomyosin protein purified from chicken embryo fibroblasts (CEF) and chicken leg, heart, and gizzard.
Target Information
Tropomyosin is a dimeric coiled-coil protein that binds along the length of actin filaments. It is associated with the thin filaments of muscle cells and the microfilaments of nonmuscle cells. Chicken embryo fibroblasts (CEF) contain five isoforms of tropomyosin (a, b, 1, 2, and 3), identified as such by their different apparent molecular masses after separation by SDS-PAGE, but similar biochemical properties, such as resistance to heat and organic solvents, the ability to bind to F-actin filaments, and the lack of proline and tryptophan.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha tropomyosin of brain; alpha tropomyosin of fibroblasts F2; alpha-Tm-1; alpha-Tm-2 isoform; Alpha-tropomyosin; alpha-tropomyosin (partial); alpha-tropomyosin 1; alpha-tropomyosin 2; alpha-tropomyosin of skeletal fast muscle; cardiomyopathy, hypertrophic 3; epididymis secretory protein Li 265; hepatoma alpha tropomyosin; myofibrillar protein; component of thin filaments; alternatively spliced; sarcomeric tropomyosin kappa; skeletal muscle tropomyosin; smooth muscle alpha-tropomyosin; striated muscle alpha-tropomyosin; TPM1-alpha; tropomyosin; tropomyosin (CTm4); tropomyosin (CTm7); tropomyosin 1 (alpha); tropomyosin 1 (alpha) isoform TPM1_1; tropomyosin 1 (alpha) isoform TPM1_2; tropomyosin 3 alpha; Tropomyosin alpha-1 chain; Tropomyosin-1; unnamed protein product
Gene Aliases: alpha-fTM; Alpha-tm; C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; Tma2; TMSA; TPM1; Tpma; tropomyosin-1
UniProt ID: (Chicken) P04268, (Human) P09493, (Rat) P04692
Entrez Gene ID: (Chicken) 396366, (Human) 7168, (Rat) 24851
protein binding
cytoskeletal protein binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
actin filament binding
actin binding
structural constituent of cytoskeleton
structural constituent of muscle
protein N-terminus binding
actin binding motor protein
muscle contraction
actin filament organization
cardiac muscle contraction
positive regulation of heart rate by epinephrine
regulation of muscle contraction
cytoskeleton organization
regulation of heart contraction
regulation of cell shape
muscle filament sliding
negative regulation of cell migration
ruffle organization
cellular response to reactive oxygen species
wound healing
sarcomere organization
positive regulation of cell adhesion
positive regulation of stress fiber assembly
ventricular cardiac muscle tissue morphogenesis
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
in utero embryonic development
positive regulation of ATPase activity
regulation of ATPase activity
actin filament capping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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