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Invitrogen
NGFR Monoclonal Antibody (NGFR5)
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FIGURE: 1 / 12
NGFR Antibody (MA5-13314) in ICC/IF
Immunofluorescence analysis of NGFR was performed using 70% confluent log phase SW480 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with NGFR Monoclonal Antibody (NGFR5) (Product # MA5-13314) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766)... View More
Product Details
MA5-13314
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Ferret,
Human,
Non-human primate,
Rabbit,
Rat
Published species
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
NGFR5
Immunogen
NGFR from A875 melanoma cells
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-13314 targets Neurotrophin Receptor /NGF-Receptor (p75NGFR) in FACS, ICC/IF and WB applications and shows reactivity with Feline, Ferret, Human, Rat, Non-human primate, and Rabbit samples. This antibody does not react with rat tissue in Western blot applications.
The MA5-13314 immunogen is nGFR from A875 melanoma cells.
Target Information
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16; unnamed protein product
Gene Aliases: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NTR; RNNGFRR; TNFRSF16
UniProt ID: (Human) P08138, (Rat) P07174
Entrez Gene ID: (Human) 4804, (Rabbit) 100349095, (Rat) 24596
beta-amyloid binding
transmembrane signaling receptor activity
death receptor activity
protein binding
calmodulin binding
coreceptor activity
small GTPase binding
ubiquitin protein ligase binding
signaling receptor activity
neurotrophin binding
nerve growth factor binding
neurotrophin TRKA receptor binding
Rab GTPase binding
preprotein binding
transmembrane signal receptor
cellular glucose homeostasis
hair follicle development
intracellular protein transport
apoptotic process
signal transduction
Rho protein signal transduction
nervous system development
axon guidance
central nervous system development
circadian rhythm
fibroblast growth factor receptor signaling pathway
regulation of gene expression
detection of temperature stimulus
nerve development
cell differentiation
negative regulation of cell migration
hair follicle morphogenesis
circadian regulation of gene expression
dorsal aorta development
negative regulation of fibroblast growth factor receptor signaling pathway
regulation of cell proliferation
odontogenesis of dentin-containing tooth
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
skin development
fibroblast proliferation
positive regulation of fibroblast proliferation
rhythmic process
neuron apoptotic process
negative regulation of hair follicle development
extrinsic apoptotic signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of protein localization to nucleus
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
cellular response to beta-amyloid
positive regulation of endothelial cell apoptotic process
positive regulation of apoptotic signaling pathway
response to wounding
positive regulation of cell death
negative regulation of neuron projection development
programmed cell death
sensory perception of pain
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
negative regulation of cell death
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
regulation of glucose import in response to insulin stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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