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Invitrogen
MMP2 Monoclonal Antibody (VB3), Biotin
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Product Details
MA5-14183
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
VB3
Immunogen
Human native 72kDa MMP-2
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14183 targets MMP-2 (72kDa Collagenase IV) in IF, IP, and WB applications and shows reactivity with Human samples.
The MA5-14183 immunogen is human native 72kDa MMP-2.
Target Information
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 72 kDa gelatinase; 72 kDa type IV collagenase; CLG 4A; Collagenase; collagenase type IV precursor; collagenase type IV-A; Gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP-2; MMPs; neutrophil gelatinase; Progelatinase A; TBE-1; TBE1; unnamed protein product
Gene Aliases: CLG4; CLG4A; MMP-2; MMP-II; MMP2; MONA; TBE-1
UniProt ID: (Human) P08253
Entrez Gene ID: (Human) 4313
angiogenesis
ovarian follicle development
ovulation from ovarian follicle
luteinization
response to hypoxia
blood vessel maturation
intramembranous ossification
proteolysis
response to oxidative stress
negative regulation of cell adhesion
heart development
female pregnancy
embryo implantation
parturition
response to xenobiotic stimulus
response to mechanical stimulus
peripheral nervous system axon regeneration
response to activity
cell migration
extracellular matrix disassembly
protein catabolic process
extracellular matrix organization
positive regulation of cell migration
collagen catabolic process
response to retinoic acid
response to cytokine
cellular response to reactive oxygen species
response to nicotine
endodermal cell differentiation
response to hydrogen peroxide
positive regulation of apoptotic process
response to estrogen
negative regulation of vasoconstriction
ephrin receptor signaling pathway
macrophage chemotaxis
positive regulation of smooth muscle cell proliferation
skeletal system morphogenesis
tissue remodeling
response to electrical stimulus
response to hyperoxia
face morphogenesis
bone trabecula formation
prostate gland epithelium morphogenesis
trophoblast cell migration
cellular response to amino acid stimulus
cellular response to cytokine stimulus
cellular response to interleukin-1
cellular response to estradiol stimulus
cellular response to UV-A
cellular response to fluid shear stress
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
response to amyloid-beta
positive regulation of vascular smooth muscle cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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