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Invitrogen
p130Cas Monoclonal Antibody (CAS-14 (35B-1A4))
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Product Details
MA5-14276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
CAS-14 (35B-1A4)
Immunogen
Recombinant human p130Cas protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14276 targets p130Cas in IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples.
The MA5-14276 immunogen is recombinant human p130Cas protein.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCA1; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; Breast cancer anti-estrogen resistance protein 1; Cas scaffolding protein family member 1; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130cas; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; unnamed protein product; v-crk-associated tyrosine kinase substrate
Gene Aliases: BCAR1; CAS; CAS1; CASS1; CRKAS; P130CAS
UniProt ID: (Human) P56945, (Rat) Q63767
Entrez Gene ID: (Human) 9564, (Rat) 25414
regulation of cell growth
actin filament organization
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
insulin receptor signaling pathway
positive regulation of endothelial cell migration
cell migration
positive regulation of cell migration
cellular response to hepatocyte growth factor stimulus
regulation of apoptotic process
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
antigen receptor-mediated signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
cell division
cell chemotaxis
endothelin receptor signaling pathway
signal transduction
actin cytoskeleton organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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