Search

  • 訂單查詢
  • 快速訂購

Invitrogen

Phospho-TrkA/TrkB (Tyr490, Tyr516) Monoclonal Antibody (H.652.3)

1 Published Figure
1 Reference
View all (7) TrkA/TrkB antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-TrkA/TrkB (Tyr490, Tyr516) Monoclonal Antibody (H.652.3)

Product Details

MA5-14926

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunoprecipitation (IP)

1:50
-
Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

H.652.3

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pTyr490 of human TrkA
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

152 µg/mL

Amount

15.2 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980032

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine receptor kinase type 2; NTRK2; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; trk tyrosine-specific protein kinase; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB; TrkB tyrosine kinase; TrkB-T-Shc; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tropomyosin-related kinase B; truncated trkB; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B; unnamed protein product

View more View less

Gene Aliases: DEE58; EIEE58; GP145-TrkB; MTC; NTRK1; NTRK2; OBHD; p140-TrkA; RATTRKB1; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1

View more View less

UniProt ID: (Human) P04629, (Human) Q16620, (Rat) P35739, (Rat) Q63604

View more View less

Entrez Gene ID: (Human) 4914, (Human) 4915, (Rat) 59109, (Rat) 25054

View more View less

Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding protease binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity ephrin receptor binding transmembrane signal receptor
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development axon guidance learning or memory circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development positive regulation of neuron projection development peptidyl-tyrosine phosphorylation olfactory nerve development cell differentiation B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity neuron apoptotic process response to hydrostatic pressure response to electrical stimulus positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus vasculogenesis neuron migration learning feeding behavior positive regulation of cell proliferation positive regulation of gene expression glutamate secretion regulation of metabolic process neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system neuron differentiation brain-derived neurotrophic factor receptor signaling pathway neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade retinal rod cell development oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis aging response to radiation response to activity sensory perception of pain response to drug response to ethanol negative regulation of neuron death inflammatory response neuromuscular junction development long-term memory response to light stimulus response to auditory stimulus positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source regulation of MAPK cascade regulation of neurotransmitter secretion regulation of dendrite development cellular response to tumor necrosis factor positive regulation of glucocorticoid receptor signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support