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Invitrogen
NQO1 Monoclonal Antibody (A180), DyLight™ 650
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FIGURE: 1 / 1
NQO1 Antibody (MA5-16098) in Flow
Flow cytometry analysis of NQO1 in U-87 cells. Samples were incubated with NQO1 monoclonal antibody (Product # MA5-16098) using a dilution of 2.5 µg/mL for 30 minutes at room temperature. An intracellular stain was performed with primary antibody (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-16098
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
A180
Immunogen
Full length recombinant NQO1 from human lung.
Conjugate
DyLight™ 650
DyLight™ 650
DyLight™ 650
Excitation/Emission Max
651/673 nm
View spectra
Form
Liquid
Concentration
0.60 mg/mL
Amount
60 µg
Purification
Protein G
Storage buffer
50mM sodium borate
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Altered expression of the protein has been seen in many tumors and is also associated with Alzheimer's disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: azoreductase; Diaphorase (NADH/NADPH); diaphorase (NADH/NADPH) (cytochrome b-5 reductase); Diaphorase 4; diaphorase 4 (NADH/NADPH); diaphorase-4; dioxin-inducible 1; DT-diaphorase; DTD; menadione reductase; NAD(P):menadione oxidoreductase; NAD(P)H dehydrogenase (quinone); NAD(P)H dehydrogenase, quinone 1; NAD(P)H menadione oxidoreductase 1, dioxin inducible; NAD(P)H-quinone oxidoreductase; NAD(P)H:menadione oxidoreductase; NAD(P)H:menadione oxidoreductase (EC 1.6.99.2); NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; NQ01; Nqo1; phylloquinone reductase; QR1; quinone reductase (EC 1.6.99.2); quinone reductase 1; unnamed protein product
Gene Aliases: DHQU; DIA4; DTD; Nmo-1; Nmo1; NMOR1; NMORI; Ox-1; Ox1; QR1
UniProt ID: (Human) P15559, (Mouse) Q64669, (Rat) P05982
Entrez Gene ID: (Dog) 610935, (Human) 1728, (Mouse) 18104, (Rat) 24314
protein polyubiquitination
ubiquinone metabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
response to oxidative stress
synaptic transmission, cholinergic
response to toxic substance
removal of superoxide radicals
protein catabolic process
response to lipopolysaccharide
cellular response to oxidative stress
negative regulation of protein catabolic process
vitamin E metabolic process
vitamin K metabolic process
innate immune response
cell redox homeostasis
negative regulation of ferroptosis
superoxide metabolic process
response to xenobiotic stimulus
negative regulation of apoptotic process
negative regulation of catalytic activity
positive regulation of neuron apoptotic process
response to caloric restriction
cellular response to hydrogen peroxide
positive regulation of NAD metabolic process
response to L-glutamine
response to ischemia
response to nutrient
response to hormone
response to carbohydrate
response to estradiol
response to testosterone
response to alkaloid
response to ethanol
response to electrical stimulus
cellular response to metal ion
response to tetrachloromethane
response to hydrogen sulfide
response to flavonoid
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