Search
Invitrogen
ROR gamma Monoclonal Antibody (4G419)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
ROR gamma Antibody (MA5-16227) in WB
Western blot analysis of ROR gamma in various lysates. Samples were incubated with ROR gamma monoclonal antibody (Product # MA5-16227) using a dilution of 5 µg/mL. (A) human thymus lysate, (B) transfected 293 cell lysate, and (C) untransfected 293 cell lysate.
Product Details
MA5-16227
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4G419
Immunogen
A portion of amino acids 1-50 of human ROR gamma.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; RORC; Thymus orphan receptor; TOR; unnamed protein product
Gene Aliases: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR
UniProt ID: (Human) P51449, (Mouse) P51450
Entrez Gene ID: (Human) 6097, (Rat) 368158, (Mouse) 19885
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
sequence-specific double-stranded DNA binding
molecular_function
steroid hormone receptor activity
transcription coactivator binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
xenobiotic metabolic process
circadian rhythm
regulation of gene expression
regulation of glucose metabolic process
regulation of steroid metabolic process
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
T-helper cell differentiation
positive regulation of circadian rhythm
regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
rhythmic process
lymph node development
Peyer's patch development
adipose tissue development
negative regulation of thymocyte apoptotic process
T-helper 17 cell differentiation
transcription, DNA-templated
steroid hormone mediated signaling pathway
protein phosphorylation
multicellular organism development
cell differentiation
interleukin-17 production
T cell differentiation in thymus
regulation of gamma-delta T cell differentiation
alpha-beta T cell differentiation
mucosal-associated lymphoid tissue development
regulation of transcription involved in cell fate commitment
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support