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Invitrogen
Dectin 1 (soluble) Monoclonal Antibody (2A11), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-16482
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2A11
Immunogen
Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Protein G
Storage buffer
PBS with 1% BSA, 5% sucrose
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.25 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark. Once reconstituted, this product has a shelf life of approx. 18 months.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Rat anti Mouse Dectin-1 antibody, clone 2A11 recognizes murine beta-glucan receptor, also known as Dectin-1.
Rat anti Mouse Dectin-1 antibody, clone 2A11 recognizes murine beta-glucan receptor, also known as Dectin-1.
Target Information
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin superfamily member 12; DC-associated C-type lectin 1; dectin-1; dendritic cell-associated C-type lectin 1
Gene Aliases: beta-GR; BGR; Clecsf12
Entrez Gene ID: (Mouse) 56644
cell activation
response to yeast
detection of yeast
stimulatory C-type lectin receptor signaling pathway
response to molecule of fungal origin
leukocyte activation involved in immune response
positive regulation of cytokine production involved in immune response
positive regulation of dendritic cell cytokine production
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
phagocytosis, engulfment
cell recognition
positive regulation of cell proliferation
positive regulation of gene expression
detection of fungus
positive regulation of cell migration
positive regulation of protein complex assembly
detection of molecule of fungal origin
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
positive regulation of superoxide anion generation
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
leukocyte activation
positive regulation of nitric oxide biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phagocytosis
positive regulation of calcium-mediated signaling
positive regulation of lymphocyte activation
positive regulation of respiratory burst
antifungal innate immune response
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
cellular response to molecule of fungal origin
positive regulation of monocyte chemotactic protein-1 production
positive regulation of wound healing
apoptotic signaling pathway
cell-cell adhesion
positive regulation of cytokine production involved in inflammatory response
positive regulation of cell maturation
positive regulation of T-helper 17 type immune response
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