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Invitrogen

CD36 Monoclonal Antibody (MF3)

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CD36 Monoclonal Antibody (MF3)

Product Details

MA5-16831

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

MF3

Immunogen

IL-4 treated murine thioglycollate-elicited peritoneal macrophages.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538310

Product Specific Information

This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01EU/ug.

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Rat anti Mouse CD36 antibody, clone MF3 recognizes mouse CD36, also known as platelet glycoprotein 4, glycoprotein IIIb or PAS IV.

Target Information

CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD36; fatty acid translocase; Glycoprotein IIIb; GPIIIB; GPIV; PAS IV; PAS-4; Platelet glycoprotein 4; Platelet glycoprotein IV; SR-B3

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Gene Aliases: Cd36; FAT; GPIV; Scarb3

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UniProt ID: (Mouse) Q08857

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Entrez Gene ID: (Mouse) 12491

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Function(s)
low-density lipoprotein receptor activity protein binding high-density lipoprotein particle binding lipid binding low-density lipoprotein particle binding transforming growth factor beta binding thrombospondin receptor activity oleic acid binding lipoteichoic acid receptor activity lipoprotein particle binding membrane trafficking regulatory protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter long-chain fatty acid metabolic process positive regulation of cell-matrix adhesion pattern recognition receptor signaling pathway negative regulation of systemic arterial blood pressure fatty acid metabolic process triglyceride metabolic process transport receptor-mediated endocytosis phagocytosis, recognition cell adhesion signal transduction cell surface receptor signaling pathway nitric oxide mediated signal transduction response to mechanical stimulus negative regulation of gene expression positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol storage fatty acid transport long-chain fatty acid transport plasma membrane long-chain fatty acid transport negative regulation of angiogenesis fatty acid oxidation lipid storage cGMP-mediated signaling positive regulation of blood coagulation cholesterol transport positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production plasma lipoprotein particle clearance low-density lipoprotein particle clearance lipoprotein transport negative regulation of transcription factor import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic cell clearance positive regulation of MAPK cascade regulation of transcription from RNA polymerase II promoter in response to oxidative stress negative regulation of growth of symbiont in host long-chain fatty acid import positive regulation of cytokine secretion positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium low-density lipoprotein particle mediated signaling positive regulation of phagocytosis, engulfment positive regulation of macrophage cytokine production cellular response to bacterial lipopeptide cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to hydroperoxide regulation of removal of superoxide radicals positive regulation of blood microparticle formation positive regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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