Search
Invitrogen
CD49f Monoclonal Antibody (NKI-GoH3)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-16884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cynomolgus monkey,
Human,
Mouse,
Sheep,
Pig
Published species
Goat,
Human,
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
NKI-GoH3
Immunogen
BALB/c mouse mammary tumour cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. A suggested positive control for immunohistochemical applications is human tonsil.
Target Information
CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD49 antigen-like family member F; CD49f; DKFZp686J01244; extracellular matrix receptor subunit; FLJ18737; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; unnamed protein product; very late activation protein 6; VLA-6
Gene Aliases: 5033401O05Rik; AI115430; CD49f; ITGA6; ITGA6A; ITGA6B; JEB6; VLA-6
UniProt ID: (Human) P23229, (Mouse) Q61739
Entrez Gene ID: (Human) 3655, (Cynomolgus monkey) 101925271, (Pig) 100158200, (Dog) 100856563, (Sheep) 101113656, (Mouse) 16403
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
ectodermal cell differentiation
positive regulation of neuron projection development
positive regulation of cell migration
cell-substrate adhesion
nail development
positive regulation of apoptotic process
positive regulation of GTPase activity
skin morphogenesis
positive regulation of transcription from RNA polymerase II promoter
leukocyte migration
cell-cell adhesion
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of cell-substrate adhesion
single organismal cell-cell adhesion
positive regulation of cell-cell adhesion
cellular response to extracellular stimulus
cell adhesion mediated by integrin
positive regulation of phosphorylation
odontogenesis of dentin-containing tooth
skin development
filopodium assembly
digestive tract development
brown fat cell differentiation
renal system development
amelogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support