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Invitrogen

MCP-1 Monoclonal Antibody (2D8)

22 Published Figures
38 References
View all (66) CCL2 (MCP-1) antibodies

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Product Details

MA5-17040

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 9 publications 9 publications

Immunohistochemistry (IHC)

-
View 16 publications 16 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:200-1:1,000
View 4 publications 4 publications

Flow Cytometry (Flow)

1:200-1:400
View 2 publications 2 publications

ELISA (ELISA)

1:10,000
View 2 publications 2 publications

Neutralization (Neu)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D8

Immunogen

Purified recombinant fragment of human CCL2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538512

Product Specific Information

MA5-17040 targets CCL2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples.

The MA5-17040 immunogen is purified recombinant fragment of human CCL2 expressed in E. Coli.

MA5-17040 detects CCL2 which has a predicted molecular weight of approximately 11kDa.

Target Information

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; chemotactic and activating factor precursor; Genbank Staff Annotation: The small inducible cytokine A2 (SWISS-PROT ACC P13500) is encoded in this mRNA, although it is interrupted and partial, perhaps indicating that this CDS is not the true product of the gamma.1 gene.; H-MCP-1; HC11; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; monocyte chemotactic protein; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Mutations: 171:OK; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; Small-inducible cytokine A2; unnamed protein product

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Gene Aliases: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF

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UniProt ID: (Human) P13500, (Mouse) P10148

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Entrez Gene ID: (Human) 6347, (Mouse) 20296

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Function(s)
protein kinase activity receptor binding cytokine activity protein binding chemokine activity CCR2 chemokine receptor binding chemoattractant activity CCR chemokine receptor binding G-protein coupled receptor binding heparin binding cytokine intercellular signal molecule
Process(es)
angiogenesis monocyte chemotaxis protein phosphorylation chemotaxis inflammatory response immune response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade regulation of cell shape response to bacterium organ morphogenesis positive regulation of gene expression positive regulation of macrophage chemotaxis viral genome replication cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis positive regulation of cell migration negative regulation of glial cell apoptotic process helper T cell extravasation chemokine (C-C motif) ligand 2 signaling pathway negative regulation of neuron apoptotic process astrocyte cell migration cellular response to fibroblast growth factor stimulus eosinophil chemotaxis macrophage chemotaxis positive regulation of T cell activation positive chemotaxis positive regulation of synaptic transmission, glutamatergic antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of calcium ion import positive regulation of glutamate receptor signaling pathway negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response positive regulation of leukocyte migration positive regulation of cellular extravasation cellular calcium ion homeostasis transforming growth factor beta receptor signaling pathway glial cell migration response to heat response to wounding regulation of vascular endothelial growth factor production negative regulation of angiogenesis positive regulation of cell-cell adhesion neutrophil chemotaxis positive regulation of tumor necrosis factor production positive regulation of collagen biosynthetic process monocyte homeostasis positive regulation of cell adhesion vascular endothelial growth factor receptor signaling pathway lymphocyte chemotaxis positive regulation of synaptic transmission positive regulation of nitric-oxide synthase biosynthetic process positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of protein targeting to membrane
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