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Invitrogen
CD45RC Monoclonal Antibody (OX-22), PE
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17462
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OX-22
Immunogen
Phytohaemagglutinin-activated rat lymph node cells
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
50 µg
Purification
Protein G
Storage buffer
PBS with 4-5mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17462 targets CD45RC in FACS applications and shows reactivity with Rat samples.
The MA5-17462 immunogen is phytohaemagglutinin-activated rat lymph node cells.
Target Information
CD45RC (PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. It acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, the second affects the substrate specificity of the first. Upon T-cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leucocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte-common antigen precursor; protein tyrosine phosphatase, receptor-type, c polypeptide; T200 glycoprotein
Gene Aliases: CD45; L-CA; Lca; RT7; T200
UniProt ID: (Rat) P04157
Entrez Gene ID: (Rat) 24699
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
receptor binding
protein binding
heparin binding
protein kinase regulator activity
protein kinase binding
protein tyrosine kinase inhibitor activity
ankyrin binding
spectrin binding
heparan sulfate proteoglycan binding
negative regulation of transcription from RNA polymerase II promoter
natural killer cell differentiation
negative regulation of T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity
negative regulation of cytokine-mediated signaling pathway
hematopoietic progenitor cell differentiation
positive regulation of immunoglobulin production
positive regulation of T cell mediated immunity
regulation of humoral immune response mediated by circulating immunoglobulin
positive regulation of humoral immune response mediated by circulating immunoglobulin
negative regulation of protein kinase activity
protein dephosphorylation
negative regulation of cell adhesion involved in substrate-bound cell migration
leukocyte cell-cell adhesion
signal transduction
response to gamma radiation
regulation of gene expression
dephosphorylation
B cell differentiation
T cell differentiation
positive regulation of B cell proliferation
negative regulation of protein autophosphorylation
regulation of interleukin-8 production
negative regulation of interleukin-2 production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
heterotypic cell-cell adhesion
T cell proliferation
B cell proliferation
positive regulation of T cell proliferation
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
cell cycle phase transition
plasma membrane raft distribution
positive thymic T cell selection
negative thymic T cell selection
positive regulation of T cell differentiation
positive regulation of gamma-delta T cell differentiation
negative regulation of JAK-STAT cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of isotype switching to IgG isotypes
bone marrow development
stem cell development
negative regulation of peptidyl-tyrosine phosphorylation
regulation of phagocytosis
positive regulation of phagocytosis
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
B cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of antigen receptor-mediated signaling pathway
release of sequestered calcium ion into cytosol
defense response to virus
regulation of cell cycle
positive regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
negative regulation of interleukin-4-mediated signaling pathway
response to aldosterone
positive regulation of hematopoietic stem cell migration
positive regulation of stem cell proliferation
regulation of extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
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