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Invitrogen
CD200 Monoclonal Antibody (OX-2), FITC
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17565
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OX-2
Immunogen
Rat thymocyte membrane glycoproteins were fused with mouse NS-1 myeloma cells.
Conjugate
FITC
FITC
FITC
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 4-5mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cd200 antigen; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); MRC OX-2 antigen
Gene Aliases: Cspmo2; Mox2; MRCOX2
Entrez Gene ID: (Rat) 24560
negative regulation of cell proliferation
negative regulation of interleukin-6 production
heterotypic cell-cell adhesion
negative regulation of macrophage activation
positive regulation of macrophage activation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
regulation of immune response
cellular response to lipopolysaccharide
cellular response to interferon-gamma
positive regulation of transforming growth factor beta production
cell-cell adhesion
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
negative regulation of matrix metallopeptidase secretion
negative regulation of macrophage migration
negative regulation of T cell migration
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