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Invitrogen

beta-2 Microglobulin Monoclonal Antibody (YTH470.5), PE

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beta-2 Microglobulin Monoclonal Antibody (YTH470.5), PE

Product Details

MA5-17686

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.5 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

YTH470.5

Immunogen

Rat monoclonal antibody raised against human lymphocytes.
View immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS with 4-5mg/mL BSA

Contains

0.02% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539076

Product Specific Information

MA5-17686 targets Beta 2-microglobulin in FACS and WB applications and shows reactivity with Human samples.

The MA5-17686 immunogen is rat monoclonal antibody raised against human lymphocytes.

Target Information

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Bioinformatics

Protein Aliases: B-F; B2-microglobulin; B2M; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta2 microglobulin; HDCMA22P; MHC Class I; microglobulin beta-2; Orla-B2m; similar to Homo sapiens mRNA for beta 2-microglobulin with GenBank Accession Number AB021288; unnamed protein product

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Gene Aliases: AMYLD6; B2M; CDABP0092; HDCMA22P; IMD43; MHC1D4

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UniProt ID: (Human) P61769

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Entrez Gene ID: (Human) 567

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Function(s)
structural molecule activity protein binding MHC class II protein complex binding peptide antigen binding identical protein binding protein homodimerization activity
Process(es)
T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity response to molecule of bacterial origin immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent peptide antigen assembly with MHC class I protein complex peptide antigen assembly with MHC class II protein complex positive regulation of T cell cytokine production regulation of membrane depolarization iron ion transport cellular iron ion homeostasis immune response sensory perception of smell learning or memory response to metal ion negative regulation of neuron projection development antibacterial humoral response antigen processing and presentation of endogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class II T cell differentiation in thymus transferrin transport regulation of iron ion transport negative regulation of iron ion transport protein refolding innate immune response regulation of erythrocyte differentiation positive regulation of receptor-mediated endocytosis negative regulation of receptor-mediated endocytosis negative regulation of epithelial cell proliferation negative regulation of neurogenesis positive regulation of immune response defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of T cell activation protein homotetramerization multicellular organismal iron ion homeostasis antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide cellular response to iron ion cellular response to iron(III) ion cellular response to nicotine amyloid fibril formation positive regulation of cellular senescence negative regulation of forebrain neuron differentiation
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