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Invitrogen

CD45R Monoclonal Antibody (YTH80.103)

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View all (101) B220 (CD45R) antibodies

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Product Details

MA5-17692

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunocytochemistry (ICC/IF)

1:500
-

Flow Cytometry (Flow)

1.0 µg/1x10^6 cells
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Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

YTH80.103

Immunogen

Rat monoclonal antibody raised against human CD45R

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539082

Product Specific Information

MA5-17692 targets CD45R in FACS and WB applications and shows reactivity with Human samples.

The MA5-17692 immunogen is rat monoclonal antibody raised against human CD45R.

Target Information

CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD45 antigen; glycoprotein 180; protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; T200 glycoprotein; T200 leukocyte common antigen; unnamed protein product

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Gene Aliases: B220; CD45; CD45R; GP180; IMD105; L-CA; LCA; LY5; T200

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UniProt ID: (Human) P08575

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Entrez Gene ID: (Human) 5788

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Function(s)
protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity receptor binding protein binding heparin binding protein kinase binding protein tyrosine kinase inhibitor activity ankyrin binding spectrin binding heparan sulfate proteoglycan binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter natural killer cell differentiation negative regulation of T cell mediated cytotoxicity negative regulation of cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation positive regulation of immunoglobulin production negative regulation of protein kinase activity protein dephosphorylation negative regulation of cell adhesion involved in substrate-bound cell migration signal transduction cell surface receptor signaling pathway response to gamma radiation regulation of gene expression dephosphorylation B cell differentiation T cell differentiation positive regulation of B cell proliferation regulation of interleukin-8 production negative regulation of interleukin-2 production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production B cell proliferation positive regulation of T cell proliferation T cell activation positive regulation of MAPK cascade cell cycle phase transition plasma membrane raft distribution positive regulation of protein kinase activity negative regulation of JAK-STAT cascade bone marrow development stem cell development regulation of phagocytosis positive regulation of phagocytosis positive regulation of calcium-mediated signaling T cell receptor signaling pathway B cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of antigen receptor-mediated signaling pathway release of sequestered calcium ion into cytosol defense response to virus regulation of cell cycle positive regulation of Fc receptor mediated stimulatory signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade negative regulation of interleukin-4-mediated signaling pathway negative regulation of microglial cell activation response to aldosterone DN2 thymocyte differentiation positive regulation of hematopoietic stem cell migration positive regulation of stem cell proliferation
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