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Invitrogen
I-Ak Monoclonal Antibody (14V.18), Biotin
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Product Details
MA5-17772
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
14V.18
Immunogen
A.TL spleen
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 4-5mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17772 targets I-Ak in FACS applications and shows reactivity with Mouse samples.
The MA5-17772 immunogen is a.TL spleen.
Target Information
MHC Class II (I-Ak) serves as a critical component of the immune system, facilitating the recognition and response to extracellular pathogens and foreign substances. Its primary role is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ak) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. The location of MHC Class II (I-Ak) is restricted to antigen-presenting cells, such as dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. MHC Class II (I-Ak) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A alpha; H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; histocompatibility 2, class II antigen A, alpha; IAalpha; major histocompatibility protein class II alpha chain; MHC class II antigen A alpha isoform-004; MHC-II I-A(d) alpha
Gene Aliases: Aalpha; H-2Aa; H2-Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha
UniProt ID: (Mouse) P14434
Entrez Gene ID: (Mouse) 14960
immune system process
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
response to interferon-gamma
negative regulation of T cell proliferation
positive regulation of T cell differentiation
antigen processing and presentation of peptide antigen
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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